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*Correspondence: Xiaoming Zhou, [email protected] This article was submitted to Molecular Diagnostics and Therapeutics, a section of the journal Frontiers in Molecular Biosciences Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

A small percentage of users report sleep disturbances with evening dosing, possibly related to nitric oxide system effects

Participants were coded to ensure confidentiality, and their information was kept confidential during data analysis