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DOI: 10.1021/ar00009a003 [4] MASAYASU INOUE

This condition arises when the skins pigment-producing cellsmelanocytesbegin to produce excess melanin, which causes uneven skin tone

For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption