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For example, the antidepressant paraoxetine increased the risk of heart defects by 45%, heart valve defects by 39%, muscle and skeletal defects by 92%, and early fusing of the skull plates up by nearly 300% (a very dangerous condition that restricts brain growth)

Natural compounds or TCM formulas with ferroptosis-inhibitory effects in other kidney diseases [e.g., berberine and irisflorentin (201, 202)] have not been tested in LN, representing an untapped therapeutic avenue

Furthermore, the role of SLC25A33-mediated mtDNA synthesis and mtROS production in facilitating mtDNA release during macrophage polarization and the dysregulated inflammatory response warrants further investigation

Other methods to increase tissue glutathione levels are based on the "overshoot" of glutathione concentration, following depletion by diethylmaleate or BSO