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Curcumin dose-dependently reversed PPA-induced deficits in social interaction, repetitive behaviors, anxiety, locomotion, learning and memory, while normalizing oxidative stress, mitochondrial dysfunction and pro-inflammatory signaling, supporting its neuroprotective efficacy in this ASD model (Yang et al., 2020)

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PPAR agonists also downregulate glutathione (GSH) levels, increasing reactive oxygen species (ROS) levels, and downregulating retinoic acid receptor-related orphan receptor t (RORt) expression, which facilitates amelioration of Th17-cell-associated immune dysregulation ( Figure 2 ) (52)