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Description

Regarding inflammatory mediators, berberine significantly reduces the levels of inflammatory cytokines, including tumor necrosis factor-alpha (TNF- ), interleukin-6 (IL-6), and IL-1 , and downregulates their protein expression [210]

Singh AP, Singh M, Balakumar P

Hepatology 55 , 419428 (2012)

This approach specifically targets M2 macrophages and tracks their polarization with noninvasiveness and deep penetration and provides insights for detecting and inhibiting early tumor metastasis