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74 Dysfunctional telomeres arise from critically short telomeres, ultimately leading to replicative cellular senescence and chromosome instability: both hallmarks of aging

The ground-breaking finding that mice expressing dominant-negative N-cadherin, an adherent junction protein, develop spontaneous (not induced using chemicals or infections known to induce colitis in mice) inflammation in the gut epithelium further supports the key role of cell-to-cell adhesion, especially in its capacity to contribute to overall mucosal barrier function in regulating mucosal immune homeostasis

Lakke et al., 1987), normal (Kuiper et al., 2000), or decreased (Molina et al., 1997a)

Increasing the SC dose to compensate for the lower bioavailability leads to unpredictable serum concentrations and can therefore not be recommended