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To provide a comprehensive overview of the current research landscape, this chapter will explore the alterations, functions, and regulatory mechanisms of gut microbiota and their metabolites in the acclimatization to high-altitude conditions across different species

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RGCs isolated from retinas 24 h after IR show that the signaling cascades regulating ferrous iron (Fe 2+ ) metabolism, such as TNFRSF1A and FAS, undergo significant changes, which causes retinal damage after I/R (Dvoriantchikova et al., 2023)