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The acetylation of GATA4 increases its DNA binding activity and the transcription of cardiac hypertrophic response genes, including atrial natriuretic factor (ANF), brain natriuretic peptide (BNP), endothelin-1 (ET-1), and -myosin heavy chain (-MHC), leading to cardiomyocyte hypertrophy [8, 9, 10]

This reaction uses NADH as a reducing agent, which is oxidized to NAD +

Coenzym Q10 H tr vn chuyn electron trong chui phn ng h hp ca ty th t bo Tng cng sn xut nng lng di dng ATP H tr nng cao sn xut cc cht chng oxy ha khc nh: superoxide dismutase Gim tn sinh cc cht c tnh oxy ha mnh, gim peroxide ha lipid Alpha Lipoic acid

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice