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Two-site reproducibility of cerebellar and brainstem neurochemical profiles with short-echo, single-voxel MRS at 3T

Tirzepatide engages GIP near the strength of the natural hormone but activates GLP-1 about 18 times more weakly than natural GLP-1. After accounting for protein binding in blood, the drug is roughly 20-fold GIP-forward and has no meaningful glucagon activity