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It has been shown that the oral microbiome of diabetic individuals with or without periodontal disease is different from non-diabetic people, notably with a significant reduction in biological and phylogenetic diversity [27, 28]

The Type IV Phosphodiesterase Inhibitor Rolipram Induces Expression of the Cell Cycle Inhibitors P21(Cip1) and P27(Kip1), Resulting in Growth Inhibition, Increased Differentiation, and Subsequent Apoptosis of Malignant A-172 Glioma Cells

Additionally, Smad4 could be a potential therapeutic target for diabetic nephropathy

DT-diaphorase (NQO1) is a flavoprotein found in dopaminergic neurons and astrocytes