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Furthermore, disruption of MAM integrity impairs the recruitment of autophagy-initiating proteins such as ATG14L, thereby hindering the clearance of damaged ER and mitochondria and exacerbating intracellular oxidative stress ( 2+ imbalance, forming a pathological inter-organelle positive feedback loop that accelerates the progression of DCM

conducted a study in patients with PG and found higher levels of blood pressure, glucose, insulin, C-reactive protein, and HOMA index, as well as elevated IL-6 levels, compared with controls