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190198 Pathway analyses using the Kyoto Encyclopedia of Genes and Genomes (KEGG) have identified key inflammatory signaling, including cytokine-induced mitogen-activated protein (MAP) kinases, NF-B activation, and oxidative phosphorylation, as central contributors to OA pathogenesis

van Assema DME, Lubberink M, Boellaard R, Schuit RC, Windhorst AD, Scheltens P, et al

If you're designing a protocol around the assumption that short half life equals short effect, you're applying the wrong framework entirely