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(1988) Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer

134,135 IL-1 inhibition IL-1 is a cytokine that has the capability of immune and pro-inflammatory actions

Collectively, these approaches offer novel mechanistic insights and therapeutic avenues for targeting ferroptosis propagation in the AD brain

However, when ROS levels rise beyond the capacity of antioxidants, they can damage cellular macromolecules, disrupt normal cell functions, trigger mitochondria to produce pro-apoptotic proteins, and ultimately lead to the apoptosis of central nervous system neurons (Schieber and Chandel, 2014)