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Intravenous GSH has a short half-life but has shown to be effective in several diseases

Excessive activity on the liver can deplete Glutathione

Antioxidant supplements reduced oxidative stress and stabilized liver function tests but did not reduce inflammation in a randomized controlled trial in obese children and adolescents

NAC Administration Ameliorates TNBS plus Ethanol Induced Mucosal Injury To test whether the early TNBS+ethanol-induced GSH depletion was important for the development of colitis by rendering mucosa susceptible to the TNBS+ethanol-induced ROS overgeneration, we examined the effect of NAC, a GSH precursor, on both mucosal GSH content and extent of injury in TNBS+ethanol-treated rats