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This hypothesis was validated in a preclinical melanoma model, where blocking CD38 expression in T lymphocytes boosted NAD + levels, improving the effectiveness of adoptively transferred T cells ( Beside reported pharmacological inhibitors ( + pool concentrations

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Strbe et al., 2021), intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and coworkers (Chui et al., 1970) on a scale of 05 (normal to severe) in three categories (mucosal injury, inflammation, and hyperemia/hemorrhage) for a total score of 015, as described by Lane and coworkers (Lane et al., 1997)