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Here we show that treatment of mice with a non-cytotoxic heavy-chain antibody that selectively inhibits CD38 ectoenzyme resulted in NAD + boosting that was associated with significant protection from fibrosis in multiple organs

Administering even small quantities of these modified mRNA-LNPs was shown to significantly upregulate IL-12, which suppresses tumor growth by activating the cellular immune response [298]

Recommended endpoints: histology, functional assays, angiogenic markers (CD31, VEGF), and blinded scoring to reduce bias

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