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Systemic inflammation has been linked to impaired cognitive function and aberrations in brain structure in many settings (refer to the Age-Related Cognitive Decline protocol for a more thorough discussion of the role of inflammation in cognitive dysfunction)

This receptor profile has unique physiological effects, such as a noticeable decrease in stomach motility and brainstem-mediated signals of fullness

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Hypertrophy of the intima and media, sclerosis of the vascular wall, and the formation of atheromatous plaques are structural changes in the renal vessels due to aging, similar to the changes observed in vessels in other organs of the body