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Boccardi V (2025) From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan

TB-500 is a synthetic fragment of Thymosin Beta-4 whose core proposed action is the sequestering of G-actin to regulate actin polymerization the process behind cell migration in wound healing and which has been linked preclinically to angiogenesis and reduced inflammation [3] [4]

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Altogether this provided rationale for investigating the potency of FOXO4-DRI on tubular senescence and renal function in in vivo