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The downstream effects are dramatic: keratinocyte proliferation and differentiation accelerate, the epidermis compacts and normalizes, melanin transfer is disrupted (fading pigmentation), and dermal fibroblasts are stimulated to produce new collagen while matrix-degrading enzymes (MMPs) are suppressed

In catabolic circumstances, the levels of IGF-1 decrease while its binding proteins increase, leading to a lower local IGF-1 activity and contributing to the decreased insulin sensitivity seen in catabolism

Although KD has been used for many years as an individual or adjuvant therapy in the treatment of various diseases, the mechanisms of its curative effect are still not fully understood

Vitamin C supports cellular function and is involved in collagen production, which creates a physical barrier from foreign invaders that may enter through the skin