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Acidosis-induced activation of GPR4 promotes the endoplasmic reticulum (ER) stress response and apoptosis of endothelial cells (177, 179, 180)

Nature 402 , 187191 (1999)

Epigenetic therapy for cardiovascular disease DNA methylation DNA methyltransferase inhibitors or related drugs play a role in the treatment of cardiovascular diseases such as coronary heart disease and heart failure by regulating target genes methylation status and expression level (Figs