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At its core, GHK-Cu functions as a matrikine, a signaling molecule released from the extracellular matrix when tissue damage occurs

J Clin Endocrinol Metab (2004) 89:170411

The intestinal barrier is primarily maintained by tight junctions (TJs) between epithelial cells, which regulate intestinal permeability and prevent the invasion of pathogens and harmful substances into the submucosal layer