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Description

Under stress conditions, mitochondrial damage results in the production of excessive mtROS, provoking oxidative damage to mtDNA and mtDNA release into the cytoplasm through the mitochondrial permeability transition pore, which further activates the DNA sensor cGAS-STING and facilitates downstream inflammatory processes (101, 102)

Preclinical and preliminary clinical studies indicate KDs potential in modulating epigenetic markers, reducing inflammation, and improving patient metabolic health