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doi: 10.1038/s41419-023-05708-0

Ethanol oxidation alters the redox potential of the hepatocyte Ethanol oxidation results in the increased ratio of NADH to NAD + This inhibits oxidation of lactate to pyruvate (a step that requires NAD + as a cofactor) and also creates potential for the development of lactic acidosis

2017;61(12):e01362-e1417

After a 2 week screening period all eligible participants were randomly assigned to treatment groups receiving either a subcutaneous injection of 2.4 mg of semaglutide, 2.4 mg of cagrilintide, a combination of cagrilintide and semaglutide, a semaglutide placebo, or a cagrilintide placebo [2]