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Bazinet A, Kadia T, Short N, Borthakur G, Wang S, Loghavi S, Patel K, DiNardo C, Daver N, Alvarado Y, Haddad F, Pierce S, Andreeff M , Jabbour E, Konopleva M, Kantarjian H, Ravandi F

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D., Noakes, M., Buckley, J

It is widely acknowledged that clinically approved therapies, such as statins and PCSK9 inhibitors, offer mechanistic insight into LDLR regulation by altering cholesterol metabolism and arresting LDLR lysosomal degradation