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The findings not only deepen our understanding of PCOS pathogenesis but also establish a strong theoretical foundation for innovative microbiome-based therapeutics

However, free Cys, small thiols, and most Cys in proteins react quite poorly with H 2 O 2 , with rate constants of the order of 10 M 1 s 1 [1], indicating that their oxidation cannot be accomplished during rapid physiological peroxide fluctuations

UV radiation can excite skin cells, resulting in the generation of ROS such as singlet oxygen (1O2) and superoxide radicals [53]

160,161 For example, HM15211, a triple agonist developed by Hanmi Pharmaceutical in South Korea that activates GLP-1R, GIPR and GCGR has entered early clinical trials for the treatment of obesity and non-alcoholic steatohepatitis (NASH)