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FIGURE 2 3.1 Activation of inflammation-related signaling pathways in skin diseases ROS are important regulators of inflammatory responses, capable of activating various inflammatory signaling pathways, promoting the secretion and release of inflammatory factors, and forming a chronic inflammatory microenvironment (Figure 3)

You should also consider consulting a dermatologist for treatment if youre emotionally distressed or worried about the appearance of KP

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Nonetheless, the aforementioned animal models, although extremely useful in investigating specific molecular mechanisms in the pathogenesis of ulcerative colitis, do not truly recapitulate disease as observed in patients, as IBD is a multifactorial disease and most clearly is not caused by a single mutation or defect in cellular or molecular pathways