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One well-documented interaction is with certain anti-epileptic drugs: high-dose pyridoxine may reduce the plasma levels of phenytoin and phenobarbital by enhancing their hepatic metabolism, potentially diminishing their anticonvulsant efficacy

Semaglutide has been studied in adults 65 years of age or older during clinical trials

The use of Semaglutide / Cyanocobalamin Injection is contraindicated in several specific patient populations and clinical situations where the risks associated with treatment may outweigh potential benefits