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GLP-1R antagonism enhances antitumor immunity, inhibiting colorectal tumor growth [136]

doi: 10.1038/s41586-019-1705-2, 30

Kochergin IA, Shpilyukova YA, Lysogorskaia EV, Abramycheva NY, Zakharova MN, Illarioshkin SN (2019) Effect of Mutations in SOD1 and C9orf72 Genes on Autophagy in Lymphomonocytes in Myotrophic Lateral Sclerosis

Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R