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We showed that, on unfurling of the Munc18-1 loop, helix 11 and 12 in domain 3a bind to the central region of the VAMP2 SNARE motif, and validated its functional relevance in reconstituted assays and in living neurons

They also appear to be affected by things like pregnancy and exercise

doi: 10.1161/CIRCULATIONAHA.106.664250

Therefore, cancer cells develop rewired metabolic pathways through genetic mutations or the activation of innate recycling machinery in order to meet the increased requirements for proliferation 7,21