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GPX4 binds to reduced GSH through its selenocysteine residue and catalyzes the reduction of lipid peroxides, converting the peroxyl bond into a non-toxic hydroxyl radical, thereby maintaining the stability of cell membrane lipids (159)

Ibuprofen, in particular, possesses Nf-kB inhibitory activity that may further help reducing excess inflammation/cytokine release in COVID-19 patients ( there is no evidence supporting the association between Ibuprofen and increased risk of severity of COVID-19 , a position strengthened by a systematic review appeared 2 months later ( Several studies are accumulating and reappraising the importance of NSAIDs in COVID-19 management ( in silico screenings independently identified the COX-II inhibitor celecoxib as a potential anti-SARS-CoV-2 drug, and a very recent study still under peer review reports its beneficial effects plus famotidine in hospitalized patients ( Despite this accumulating evidence, paracetamol (PAC) was suggested as a safer and recommendable alternative for the early and domiciliary management of pain and fever in COVID-19 patients

10.3390/molecules29174044 Summary Keywords infection, anticancer, antibacterial, targets, drug development Citation Zhu K, Yuan Z, Li J and Fu A (2025) Microbial infection and treatment strategies in cancer patients

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