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21: 31236 Lorber A, Baumgartner WA, Bovy RA, et al

Consistent with this observation, PERMANOVA analysis demonstrated no statistically significant difference between pre- and post-intervention metabolomes (F = 0.2135, R = 0.0117, p = 0.857), suggesting that the GF-MKD did not induce large-scale global metabolic remodeling

In addition, miR-155 downregulates STAT3 and SOCS1 in mouse macrophages, resulting in the upregulation of pro-inflammatory cytokines TNF and IL-1b and the downregulation of anti-inflammatory cytokine IL-10 [41]