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Although the KV11 peptide did not have a considerable effect on breast cancer growth and proliferation in mice transplanted tumor models with an intense combined immune deficiency, it prevented the growth of the tumor by suppressing angiogenesis

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During most of the history of epigenetics, changes in DNA methylation, for example, could be correlated with changes in phenotype (Halabian et al., 2021), but there were no or only imperfect tools to actually experimentally alter epigenetic markers (Chandler and Jones, 1988)

However, at high concentrations, introducing this modification into both linear and circular mRNAs can negatively affect translational efficiency