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Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model

DOI: 10.1073/pnas.1525093113 Kim, J.A., Roy, R.R., Zhong, H., Alaynick, W.A., Embler, E., Jang, C., Gomez, G., Sonoda, T., Evans, R.M., Edgerton, V.R

1 Introduction Pediatric low-grade glioma (pLGG, WHO grade 1 or 2) is the most common brain tumor class in children ( 2 Molecular landscape of pLGG Advances in sequencing technologies have aided in classifying the diverse spectrum of pLGG histopathology

The sulfhydryl group (-SH) on glutathione's cysteine residue binds directly to heavy metals including mercury, lead, cadmium, and arsenic, forming glutathione-metal conjugates that can be excreted through bile and ultimately eliminated from the body