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In addition to the characteristic rash, features of classical lupus include: Profound fatigue that is unresponsive to rest Arthralgia in multiple joints and edema in multiple joints Spontaneous fever Photosensitivity in which sun exposure precipitates or aggravates the disease Alopecia or hair loss Mucous membrane lesions Raynaud's phenomenon, in which fingers and toes turn blue and white in cold temperatures Lupus complications arise when the disease infects organs of the body's middle segment

Needle size, for example, is exceedingly small, making subcutaneous administration at home relatively painless compared to larger needle gauges used with thicker medications for things like blood draws

J Clin Invest 97 : 146153