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Similarly, zinc-finger proteins, which bind zinc ions to stabilize their structures, have been targeted with metal-based compounds like aurothiomalate, which disrupt the zinc-cysteine interactions in the proteins active site, providing a novel approach to chemotherapy and against HIV (Medici et al., 2015)

To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

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These muscle repair studies have contributed to understanding of how cytoprotective and pro-migratory peptide mechanisms complement each other in the complex multicellular biology of skeletal muscle regeneration