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If baseline GH elevation begins to decline after 23 weeks on the higher dose, return to 1mg + 1mg for a 7-day washout period to allow receptor re-sensitization

C9orf72 was also shown to be a Rab guanine exchange factor (GEF) involved in the modulation of Rab activity (Iyer et al., 2018), which regulates NOX2 recruitment to phagosomes in dendritic cells (Jancic et al., 2007)