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Moreover, in vitro experiments in astrocytes found this effect to be specifically induced by Efavirenzs primary metabolite but not the parent compound

INTRODUCTION Aging is associated with the systemic accumulation of damage, leading to a gradual loss of function, deterioration of organismal health, and an increased mortality rate 1

As with many other disorders, factors such as nutritional status, neurotransmitter metabolites, oxidative stress, and environmental influences affect the metabolic profile in ASD (Zurawicz et al

Thus, high bilirubin concentrations (100 M) resulted in early necrosis, but low-to-moderate doses (0.6625 M) primarily resulted in delayed apoptosis [22]