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Therefore, the most serious effects of mitochondrial dysfunction are impaired ATP synthesis and mitochondrial DNA damage, which negatively affect chromosome segregation and impair embryonic development

The exact symptoms can differ based on which valve is affected, but they generally include: Abnormal heart murmur Irregular heartbeat Chest pain Shortness of breath, especially when lying down or after physical activity Fatigue Dizziness or fainting Abdominal swelling Swollen feet or ankles Preventing Cardiovascular Complications From Medication Patients with cardiovascular issues often take multiple medications, sometimes prescribed by several different clinicians, without considering the potential for drug interactions and filled by different pharmacists

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This double trxB, gor deletion is lethal as it abolishes the main reducing pathways responsible for maintaining the redox cycle of the cells