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North America's dominance is attributed to the rapid expansion of wellness and IV infusion clinics, high healthcare expenditure, growing consumer interest in preventive healthcare, and increasing adoption of anti-aging and antioxidant therapies

In contrast, there was no evidence of an effect of magnesium supplementation on FMD in three trials conducted in individuals undergoing hemodialysis (145) or healthy participants with normal (146) or high body mass index (BMI) (147)

However, elevated ROS levels can lead to malignant transformation, cellular damage, and even cell death (Sies and Jones, 2020

Of note, the transient increase in urinary LTE 4 in AEA following oral aspirin provocation has been observed only in allele C variants[64]