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And encapsulation of drugs in SPMM nanocomposites could not only longer drugs retention time in blood circulation, but also accurately target tumor tissues and reduce systemic toxicity

As a result, the management of UC has devolved into an unpredictable trial-and-error process-essentially a speculative attempt to determine which, and how many, of the 16 currently approved immunosuppressive drugs a patient can tolerate[54]

Lysine -hydroxybutyrylation (Kbhb) The unique chemical and physical properties of -hydroxybutyrate (BHB) enable this monocarboxylate to form covalent bonds with lysine residues, resulting in a novel post-translational modification known as -hydroxybutyrylation (Kbhb)