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doi:10.3389/fendo.2020.00284 Komal F, Khan MK, Imran M, et al

Next, L-citrulline is recycled to re-form L-arginine, while further oxidation of NO yields endogenously produced nitrite and nitrate, some of which are stored for future use and may contribute to NOS-independent NO production ( NOS-dependent NO production is facilitated by three tissue-specific NOS isozymes, namely, nNOS, eNOS, and iNOS ( Stimulation of NO production via the NOS-dependent pathway nNOS and eNOS are calciumcalmodulin-dependent enzymes responsible for the conversion of L-arginine and oxygen to L-citrulline and NO (Tousoulis et al., 2012)

How to use:Take one (1) serving daily as a dietary supplement or as directed by a physician