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It is noteworthy that SOD1 G93A astrocyte-induced motor neuron death seems in part mediated by host microglial activation [80]

IFN induction by TLR4 and cGASSTING is also driven by ANKIB1 We next investigated whether ANKIB1 plays a role in other PRRs known to induce type-I IFNs through TBK1 and IRF3