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These findings provide a novel therapeutic target for RB1 -deficient cancers

Transgenic mice overexpressing intestinal Cldn1 have been used to demonstrate consequent induction of MMP9 and pERK signalling and Notch-signalling pathway activation, leading to inhibition of goblet cell differentiation, decreased Muc2 expression and resultant mucosal inflammation (96)

doi: 10.1016/j.ijscr.2025.111179 Betsalel Adout , Imad Karam , Kafi Thomas , Sayed Ali , Aye M Thida , Sayra Ilyas , Rachelle Hamadi , Shoushtari Alavi , Maksim Agaronov , Edwin Chiu