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Gut microbiota: Animal models suggest that gut microbiota (e.g., Bifidobacterium) can modulate host urate metabolism by degrading urate precursors, highlighting the potential role of the gutkidney axis in hyperuricemia ( 2.2.4 Mechanisms of renal and intestinal urate reabsorption and excretion Renal and intestinal handling of urate relies on specific transporters to maintain systemic urate levels

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