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We're not just talking about a lack of synergy

The standard averages used in most BAC calculators, including CalculateBACs, are r = 0.73 for men and r = 0.66 for women

Rosenstock J, Frias J, Jastreboff AM, et al

In addition, it was noted that both BP and DOX work synergistically and upregulate the expression of apoptotic genes and proteins and eventually decrease the volume of tumor cells while decreasing the level of nitric oxide and estrogen and downregulating the level of pro-inflammatory cytokines in mice models with induced 4 T1 breast tumors