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In addition, in restoring intestinal mechanical barrier function, PNS can alleviate intestinal mucosal barrier damage by increasing the expression of ZO-1, claudin-1, and occludin in colonic mucosal tissue (Lu et al., 2020)

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Hesperidin (Matias et al., 2017), rutin (El-Sayed el et al., 2008), and rhamno (Omar et al., 2017) can reduce the amount of free Ca 2+ located between brain cells when fighting against neurogenic excitotoxicity and can attenuate the decrease of the mitochondrial membrane potential and increase caspase-3 activity (Lutz et al., 2015)

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