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They're a warning sign that you've gone too hard, too fast

In the past few years, significant experimental efforts have been put forward to explore the relationships between cellular oxidative processes and the modulation of cell signal transduction, collectively grouped under the concept of redox signaling (848)

Cells decode these spatial and chemical signals through thiol-based switches like reversible cysteine oxidation in phosphatases and kinases and transcriptional programs like the Keap1-NRF2 pathway, translating redox chemistry into adaptive cellular outcomes [9, 10]