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Walker et al., 1991), and the second was the advent of molecular techniques, which led to the cloning, and characterization of the human GHR , thus initiating the understanding of the pathophysiology of GHI (Amselem et al., In medicine, scientific advances often move more rapidly than the practices of clinicians, who may remain attached to the recognized, and trusted view of a certain disorder, particularly if it is rare

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In Europe, the prevalence is about 2.1%, with an annual incidence of 1.3 per 1,000 individuals