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The Gut Microbiome Affects Phase I and Phase II Enzymes The gut microbiota can also indirectly affect expression of detoxification enzymes

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Through insulin resistance (IR) and high levels of insulin and androgens, the adipose tissue is responsible for ovulatory disorders in disposed patients and the anovulation associated to obesity is responsible for higher risk of miscarriages and infertility ( In patients without ovulatory disorders, overweight and obesity extend the time to conceive, decrease the outcome of infertility treatment and increase the rates of gestational diabetes, hypertension, cesarean section, overweight newborns, perinatal mortality and morbidity

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