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Effect of nuclear GSH depletion on cell growth Plotting cell growth curves against nuclear CMFDA fluorescence shows than in control fibroblasts nuclear GSH distribution is maximal during cell proliferation (figure 5A)

These relationships are summarized in Table 2

GGsTop could represent a valuable pharmacological tool to inhibit LLF GGT activity in pulmonary disease models

Advanced analytical techniques are enabling researchers to track the compound's effects on global metabolite profiles, revealing complex interactions between NAD+ metabolism, methylation cycles, and other metabolic pathways that were previously unappreciated